ABSTRACT
Serology studies provide limited information on immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This cross-sectional study aimed to assess prevalence and determinants of anti-SARS-CoV-2 cellular immunity in a cohort of heart transplant (HT) recipients. All consecutive HT recipients followed-up at our outpatient clinic between February and June 2022 providing informed consent were included in this observational cross-sectional study. We quantified SARS-CoV-2 Spike (S)-reactive and Nucleocapsid (N)-reactive T cells using enzyme-linked immunospot assay. A positive response was defined as S or N reactivity >8 spots/2 × 105 lymphocytes. Clinical characteristics, laboratory data, immunosuppressive regimen and vaccination status were compared between patients with and without SARS-CoV-2 S-reactive T cells. Categorical variables were described as number (%) and continuous variables with median [IQR]. Among 201 patients (age 58 [45-65] years, 77% males, time since transplantation 51 months [24-81]), 97 (48%) exhibit S-specific T cells, of which 58 had in addition N-reactive T cells. CD4 and CD8 T lymphocyte count, glomerular filtration rate, immunosuppressive regimen were associated with T cell response (Table). Among patients with detectable SARS-Co-V-2 cellular immunity, numbers of S-reactive T cells were higher in patients who had detectable N-reactive T cells (277 vs 93 /106 T cells) (Figure). Our study provides new information on cellular immunity against SARS-CoV-2 in HT recipients. [ FROM AUTHOR] Copyright of Journal of Heart & Lung Transplantation is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
ABSTRACT
This Conference Proceedings volume contains the written versions of the contributions presented during the 6th International Conference on Smart City Applications.The event had been planned to organized in Safranbolu Campus of Karabuk University, Turkey. Then, it has been converted to the online conference because of the Covid-19 situation. It took place with the motto of “Virtual Safranbolu” by inspiring historical UNESCO Heritage city Safranbolu, on October 27–29, 2021. The conference provided a setting for discussing recent developments in a wide variety of topics including Geo-Smart Information Systems, Smart Cities, 3D City Modeling and Visualization, Smart Building and Home Automation, Smart Environment and Smart Agriculture, Location Based Services, GeoInformation for Mobile, Wearable Technologies and Wireless Sensor Networks, Building Information Modeling, Virtual and Augmented Reality, Big Data and Urban Data Analytics, Smart Healthcare, Smart Economy and Digital Business, Smart Education and Intelligent Learning System, and etc.The event has been a good opportunity for the more than 400 participants coming from 43 countries of the world to present and discuss topics in their respective research areas. In addition, five keynote speakers presented latest achievements on their fields;Domingos Santos “Smart Cities Strategies: Critical Sucess Factors”, Mohsen Kalantari Soltanieh “Smart buildings to Smart cities – The role of BIM and GIS integration”, Ksentini Adlen, “Zero Touch Management and Orchestration of Network Slices in 5G and Beyond Networks”, Bakr M.Aly Ahmed, “Smart Sustainable Urbanism”, Yusuf Arayıcı, “Design for Energy:Prosumer Buildings”.The 86 papers that were selected as a result of review process and presented during the conference were accepted for the final publication in the ISPRS Archives.We would like to thank all participants, organizing and scientific committee members, and session chairs for their contributions to the conference program and these Proceedings.
ABSTRACT
This Conference Proceedings volume contains the written versions of the contributions presented during the 5th International Conference on Smart City Applications.At first, the event had been planned to organized in Safranbolu Campus of Karabuk University, Türkiye. Then, it has been converted to the online conference because of the Covid-19 situation. It took place with the motto of “Virtual Safranbolu” by inspiring historical UNESCO Heritage city Safranbolu, on October 07-08, 2020. The conference provided a setting for discussing recent developments in a wide variety of topics including Geo-Smart Information Systems, Smart Cities, 3D City Modeling and Visualization, Smart Building and Home Automation, Smart Environment and Smart Agriculture, Location Based Services, GeoInformation for Mobile, Wearable Technologies and Wireless Sensor Networks, Building Information Modeling, Virtual and Augmented Reality, Big Data and Urban Data Analytics, Smart Healthcare, Smart Economy and Digital Business, Smart Education and Intelligent Learning System, and etc.The event has been a good opportunity for the more than 300 participants coming from more than 30 countries of the world to present and discuss topics in their respective research areas. In addition, four keynote speakers presented latest achievements on their fields;Alias Abdul Rahman "Smart Cities and Geo-Spatial Technologies", Şule Erten Ela "Smart Cities and Energy", Bülent Bayram "Deep learning applications for shoreline extraction from Landsat and Sentinel satellite Imagery", Attaullah Shah "Review Use of Modern Technologies in Creating Smart Cities".The 63 papers that were selected as a result of double-blind review process and presented during the conference were accepted for the final publication in the ISPRS Archives.We would like to thank all participants, organizing and scientific committee members, and session chairs for their contributions to the conference program and these Proceedings.